As described in our mental health programme strategy, Wellcome is exploring ‘core components’: the active ingredients in any intervention most likely to be making the difference.
We seek proposals from individuals or organisations to review the evidence and provide insight analysis for one core component they deem among the most likely to help address anxiety and/or depression in young people (14-24) worldwide.
Wellcome has long been a supporter of research into mental health. The work we’ve funded has led to NICE recommendations on the use of psychological therapies in the UK, including establishing the Improving Access to Psychological Therapies programme, and research into whether mindfulness training in schools can prevent the onset of mental health problems.
But some underlying problems need to be addressed before the field can make significant progress.
Mental health research is fragmented with problems described and measured in different ways. There’s little understanding of why treatments are only effective for some of the people who receive them, or how they really work.
This funding is in addition to the funding we already offer for research across all areas of neuroscience and mental health. Applications for our existing schemes won’t change, and your research won’t stand a greater or lesser chance of being funded if it includes a focus on depression and anxiety, young people or psychological therapies.
Our mental health programme began in January 2020. It is a five-year, £200 million commitment to transform how we understand, fund, prevent and treat anxiety and depression in young people.
We want to help shape a new super-discipline of mental health science in which scientists and clinicians work with a common purpose, using standardised measures and approaches.
We're committing £200 million in funding to this area, and we’ll look particularly at:
Researchers working in mental health, including psychiatrists, clinical psychologists, neuroscientists and data scientists, often work in silos.
Different disciplines use different measurement scales, there are inconsistent approaches to diagnosis and treatment, and there’s a lack of shared data.
Compare this to cancer, where it doesn’t matter whether you’re a cell biologist or a clinical oncologist – you’re working with a common purpose to cure cancer.
We want to bring the same sense of common purpose to mental health, with different disciplines working together to collaborate in a new super-discipline of mental health science.
For this to become a reality, we want to help develop:
Mental health science will generate robust scientific evidence about what works and why, allowing treatments to be tailored to the people who need them.
To build greater awareness of and support for mental health science, we’ll work closely with people who have lived experience of mental health problems, policymakers, academic researchers, charities and the private sector.
Depression and anxiety affect over half a billion people worldwide. Although there are effective treatments, many people don’t respond to them.
Clinicians often have to use trial and error to work out the best treatment, without being able to explain why one person’s treatment is different to another’s.
In an era of personalised medicine, this failure to understand some of the underlying mechanisms means mental health is falling behind other fields.
To transform how depression and anxiety are treated, we want to:
We want to apply this work to help develop new, more personalised treatments for depression and anxiety, and improve existing ones.
We brought together a range of experts to define the research and support that’s needed to be able to detect anxiety and depression earlier.