Regulation of tissue neutrophil function and survival by the interplay between oxygen and metabolite sensing pathways

Neutrophils are white blood cells that are central to the immune system’s rapid response to infection or injury. If left unchecked, however, neutrophils contribute to tissue destruction. This is particularly apparent in the lung, where their presence is associated with injury and contributes to major conditions such as chronic obstructive pulmonary disease (COPD). We currently have no treatments that target neutrophilic inflammation.

Neutrophils are specially adapted to function where both oxygen and nutrient supplies are low so targeting these special adaptations should allow us to develop new treatments. We aim to better define mechanisms by which oxygen and nutrient sensing regulate the immune response.

Our studies will help us identify future treatment strategies for COPD.