Investments

Our overall investment objective is to generate 4.0% real return over the long term.

This is to provide for real increases in annual expenditure while preserving the Trust's capital base to balance the needs of current and future beneficiaries.

We use this absolute return strategy because it aligns asset allocation with funding requirements and provides a competitive framework in which to judge individual investments.

Between 1936 and 1986, the Trust was the sole owner of the Wellcome Foundation, Henry Wellcome's drug company.

In 1986, the Trust began floating shares in the Foundation and used the proceeds to diversify its assets.

Since this first flotation, the endowment has experienced an average 14% growth every year. This has allowed us to greatly increase the funds available to disburse in charitable grants.

1936

Henry Wellcome's will creates the Wellcome Group (now the Wellcome Trust). The Group owns the Wellcome Foundation Limited, the drug company.

Death duties are considerable and have to be partially funded by selling some of Henry's historical medical collection. The remainder after death duties is £3 million.

1950s–60s

The Wellcome Foundation Limited begins developing breakthrough drugs, and sales grow from £10m a year in 1952 to £50m a year by the 1960s.

Blockbuster drugs such as Zyloric (1966) and Septrin (1967) increase sales to about £400m a year by 1977.

1981

Zovirax is developed. It becomes the world's first billion-dollar drug in 1985.

1986

Henry's will is legally amended to allow the flotation of 21% of the drug company. The Foundation becomes a public limited company, Wellcome plc.

1992

A secondary share offering raises a further £2.3bn and allows the Trust to diversify its assets further.

1995

The Foundation merges with Glaxo.

In the years up to 2001, the Trust sells out of the combined Glaxo Wellcome shares to diversify its holding.

2006

The Trust becomes the only UK-domiciled non-public sector organisation with an Aaa/AAA credit rating and the first UK charity to issue a listed bond.

Grant giving

In the Trust's first 20 years, we disbursed a total of £1.17m of dividends. Until 1972, our trustees allowed the majority of profits to be reinvested to build up the strength of the drug company.

Between 1965 and 1991, we disbursed about £100m.

Disbursements grew from £20m in 1985 to £100m in 1992 and £200m in 1994.

Over the 2017–18 financial year, our charitable disbursements were £723m.

The Wellcome Trust endowment now stands at approximately £25.9bn.

Our approach to investing is set out in our Investment policy [PDF 186KB]. This is reviewed at least every two years by our Board of Governors and Investment Committee.

Stewardship

We welcome the introduction of the FRC Stewardship Code [PDF 140KB], and support the industry's continued efforts to strengthen the role played by institutional investors in corporate governance.

Philosophy and competitive advantages

In the deliberate absence of any pre-determined strategic asset allocation, with the exception of very broad asset ranges, the following investment beliefs drive our asset allocation:

1. Sufficient liquidity must be maintained to avoid the forced sale of assets at distressed prices. Real assets offer the best long-term growth prospects and provide protection against inflationary pressures.
2. To maximise investment returns from global economic activity, the portfolio should be very broadly diversified with no innate geographical bias.
3. We seek to use the advantages of our long-term investment horizon, ability to tolerate high levels of short-term volatility, AAA balance sheet and proactive governance structure in our investment portfolio.
4. The best returns will be driven by combining aligned partnership with the strongest external managers and building in-house resource to own selected assets directly.
5. We're generally flexible about the vehicles we invest in, whether public companies or private partnerships.

Asset allocation

The net value of our investment asset base was approximately £25.9bn at 30 September 2018.

We invest across all asset classes and, for reporting purposes, split them into four areas:

• public equity
• hedge funds
• private equity
• property and infrastructure.

Wellcome Trust Bonds are stated at quoted offer price in the table above. The bonds are carried at amortised cost in the Consolidated Balance Sheet. Investment assets exclude programme-related investments.

The investment asset allocation presents net investment assets by investment strategy rather than the statutory asset and liabilities classification basis presented in the Financial Statements. For example, the market value of Long Only Equities Global is the net market value of the equities, cash, investment debtors and investment creditors held within portfolios with a Global Equities investment strategy.

Public equity

A significant portion of our portfolio is invested in shares listed on equity markets around the world. We do this both directly through a portfolio of shares managed by our Investment team and through third-party managers.

There's no innate geographical bias in our equity portfolio – we're focused on owning well-managed businesses that are best able to take advantage of economic opportunities around the world.

When we appoint external equity managers to manage money on our behalf, we prefer active managers who share our long-term time horizon and run concentrated portfolios.

Illiquid assets

Hedge funds

We are one of the largest institutional investors in hedge funds.

We're prepared to consider a variety of approaches but avoid funds that employ substantial leverage to achieve returns. In general, most of the funds we invest in are closed to new investors.

Private equity

We have major exposure to private equity. This is mainly through partnerships with well-established buyout and venture groups across a broad range of locations and sectors.

We also selectively co-invest in direct opportunities alongside external managers.

Property and infrastructure

We have a global portfolio of property. Our major asset is our freehold estate in South Kensington, London.

Investment in commercial property and infrastructure is driven by finding attractive value propositions at the appropriate risk profile.

Risk management

We are very focused on both the qualitative and quantitative risks we take in our investments.

Our Investments team focuses on qualitative risk by continually meeting managers and through ongoing due diligence. Our internal risk and performance team analyses the overall portfolio risk. Investment risk is monitored and managed through a policy of holistic measurement using the following parameters:

• currency risk
• equity market beta (expectation of movement in the portfolio given a certain percentage change in global equity markets)
• liquidity and forecast cash holdings
• value-at-risk
• measures of diversification and exposure.