Determining how distinct vertebrate promoter classes coordinate cis-regulatory input

The appropriate use of gene-encoded information relies on an orchestrated crosstalk between gene promoters and distal regulatory elements in the genome. Angelika aims to discover the molecular and structural features that dictate how mammalian gene promoters coordinate communication with such elements. This will form the basis from which to understand how these systems are perturbed in human disease. During the course of her fellowship, Angelika will work with Professors Robert Klose and Jim Hughes (University of Oxford) and Professors Chris Ponting and Wendy Bickmore (University of Edinburgh) to combine molecular, computational and evolutionary approaches to understand these fundamental processes.