Use of proteomics and systems biology to dissect the molecular adaptability of metabolism in muscle and fat cells

Daniel is currently working with Professor David James at the Garvan Institute in Sydney, using proteomic techniques and systems analysis to interrogate insulin action. He is particularly interested in the regulation of metabolism by insulin signalling and how this is perturbed in insulin-resistant states. He is hosted by Kei Sakamoto at the Protein Phosphorylation Unit at the University of Dundee, who has expertise in energy-stress signalling – another signalling pathway that impacts on metabolism. By understanding how distinct signalling pathways interact to control cellular metabolism, Daniel hopes to reveal aspects of this network that are dysregulated in disease states.