Molecular mechanisms regulating the kinetochore-microtubule interaction in mitosis

Tomo’s research goal is to understand how cells ensure proper chromosome segregation prior to cell division. Proper chromosome segregation is required for cells to maintain their genetic integrity. Failure in this process can lead to cell death or various human diseases, such as cancers and congenital disorders, which are characterised by chromosome instability and aneuploidy. Revealing the mechanisms for high-fidelity chromosome segregation should provide clues to understanding how various human diseases develop. Tomo’s group currently investigates how kinetochores initially interact with spindle microtubules, how this interaction develops, and how any error could be corrected to ensure proper chromosome segregation.