Grants awarded

The causal map of the human phenome

Grantholder:

Dr Gibran Hemani

University of Bristol

United Kingdom

The human phenome – the collection of all possible human characteristics – is vast and includes measures from the molecular level to whole-body physiology. These characteristics vary dramatically between tissues, time points and people. It could be that this variation is driving disease.

I will use genetic data from millions of people to construct an atlas describing the causal relationships that link every available molecular measure to every available disease phenotype. This will span billions of relationships.

A model like this can be used to understand what happens if we upset the system. I will use the model to infer the past and future trajectories of human evolution and predict the safety and effectiveness of new drugs.