Grants awarded

Structural mechanics in subcellular structure formation

Grantholder:

Dr David Murray

University of Dundee

United Kingdom

Cells harbour structures that define their function. The regulation and mechanisms of the machinery that coordinate these structures are generally poorly understood, although it is known that signalling in development of cancer results in drastic changes to this area. I aim to understand the mechanics of this machinery.

I will use a reconstitution approach, building the system from minimal components through to its full complexity using protein biochemistry and membrane biophysical methods. I will explore the cellular consequences of disruptions to the coordinating machinery. The outcome of these studies will be a comprehensive model for regulation and the structural basis for coordination of subcellular structures.

An understanding of the basic mechanisms has the long-term potential for new opportunities in the treatment of cancer.